The prenatal origins of cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24599217.
- Also identified by DOI 10.1038/nrc3679 and PMC identifier 4041218.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The concept that some childhood malignancies arise from postnatally persistent embryonal cells has a long history. Recent research has strengthened the links between driver mutations and embryonal and early postnatal development. This evidence, coupled with much greater detail on the cell of origin and the initial steps in embryonal cancer initiation, has identified important therapeutic targets and provided renewed interest in strategies for the early detection and prevention of childhood cancer.
Medical subject headings
- Cerebellar Neoplasms
- Medulloblastoma
- Neuroblastoma