C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 24599260.
- Also identified by DOI 10.1371/journal.pone.0090570 and PMC identifier 3944090.
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Abstract
We generated C57BL/6NTac mice carrying a tyrosinase loss-of function mutation and a reversion of the nonagouti locus to agouti. This strain has a high superovulation response, allows visual detection of chimeric coat color contribution of C57BL/6 ES-cells and provides a simplified breeding format that generates black G1 offspring of pure inbred C57BL/6 background in one step, providing the ideal host for genetically manipulated C57BL/6 ES cells.
Medical subject headings
- Agouti Signaling Protein
- Embryonic Stem Cells