Increased HIV-1 activity in anal high-grade squamous intraepithelial lesions compared with unaffected anal mucosa in men who have sex with men.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 24604897.
- Also identified by DOI 10.1093/cid/ciu133.
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Abstract
We studied 3 patients with focal intra-anal tissue high-grade squamous intraepithelial lesions (HSILs). All had increased human immunodeficiency virus type 1 (HIV-1) RNA and DNA in lesions compared with that in healthy mucosa. HIV-1 RNA and HIV-1 episomal DNA were indicative of ongoing viral replication, more so in anal HSILs.
Medical subject headings
- Anus Neoplasms
- Carcinoma in Situ
- Carcinoma, Squamous Cell
- HIV Infections
- HIV-1
- Homosexuality, Male
- Viral Load