The lure of a LYR: The logistics of iron sulfur cluster delivery.
other · Level V
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- Record sourced from PubMed, PMID 24606893.
- Also identified by DOI 10.1016/j.cmet.2014.02.011.
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Abstract
How are nascent iron-sulfur (Fe-S) clusters directed to specific recipient proteins? In this issue of Cell Metabolism, Maio et al. (2014) show that the mitochondrial Fe-S cochaperone protein HSC20 guides nascent Fe-S clusters based on a highly conserved motif, LYR, that exists in target proteins in different molecular contexts.
Medical subject headings
- Iron-Sulfur Proteins
- Molecular Chaperones