Independent control of aging and axon regeneration.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 24606896.
- Also identified by DOI 10.1016/j.cmet.2014.02.014 and PMC identifier 4049281.
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Abstract
Axon regeneration capacity often declines with age. One might assume that loss of regeneration is an obvious consequence of organismal aging. However, in the latest issue of Neuron, Byrne et al. (2014) demonstrate that regeneration ability and aging are regulated cell-autonomously within neurons, and can be decoupled.
Medical subject headings
- Aging
- Insulin
- Insulin-Like Growth Factor I
- Nerve Degeneration
- Nerve Regeneration
- Signal Transduction