When half is better than the whole: advances in haploid embryonic stem cell technology.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24607398.
- Also identified by DOI 10.1016/j.stem.2014.02.001.
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Abstract
Recent advances in embryonic stem cell (ESC) derivation and genome editing offer efficient platforms for genetic screening. In this issue, Li et al. and Leeb et al., respectively, expand such applications by generating haploid rat ESCs for screening, mutagenesis, and CRISPR-Cas-mediated gene targeting and by developing a forward genetic screen for interrogating haploid mESCs.
Medical subject headings
- Embryonic Stem Cells
- Genetic Techniques
- Genetic Testing
- Haploidy