Heps with pep: direct reprogramming into human hepatocytes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24607399.
- Also identified by DOI 10.1016/j.stem.2014.02.010.
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Abstract
The limited supply and expansion capacity of primary human hepatocytes presents major challenges for pharmaceutical applications and development of cell-based therapies for liver diseases. Now in Cell Stem Cell, two papers demonstrate efficient direct reprogramming of human fibroblasts into induced hepatocytes, which exhibit metabolic properties similar to primary hepatocytes.
Medical subject headings
- Cell Lineage
- Cellular Reprogramming
- Fibroblasts
- Hepatocytes