Periosteum-mimetic structures made from freestanding microgrooved nanosheets.

Shi, Xuetao; Fujie, Toshinori; Saito, Akihiro; Takeoka, Shinji; Hou, Ying; Shu, Yiwei; Chen, Mingwei; Wu, Hongkai et al. · Adv Mater · 2014

basic_science · Level V

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Abstract

A "sticker-like" PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and can harness the spatial arrangements of cells, which make it a promising candidate for generating biomimic periosteum for bone regenerative applications.

Medical subject headings