A mixed incoherent feed-forward loop allows conditional regulation of response dynamics.
basic_science · Level V
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- Record sourced from PubMed, PMID 24621982.
- Also identified by DOI 10.1371/journal.pone.0091243 and PMC identifier 3951346.
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Abstract
Expression of the SodA superoxide dismutase (MnSOD) in Escherichia coli is regulated by superoxide concentration through the SoxRS system and also by Fur (Ferric uptake regulator) through a mixed incoherent feed forward loop (FFL) containing the RyhB small regulatory RNA. In this work I theoretically analyze the function of this feed forward loop as part of the network controlling expression of the two cytoplasmic superoxide dismutases, SodA and SodB. I find that feed forward regulation allows faster response to superoxide stress at low intracellular iron levels compared to iron rich conditions. That is, it can conditionally modulate the response time of a superimposed transcriptional control mechanism.
Medical subject headings
- Bacterial Proteins
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Superoxide Dismutase