Is DNA methylation of tumour suppressor genes epigenetic?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24623307.
- Also identified by DOI 10.7554/eLife.02475 and PMC identifier 3949415.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In colorectal cancer cells, a non-epigenetic transcriptional pathway that is mediated by an oncogene maintains DNA methylation of tumour suppressor genes.
Medical subject headings
- CpG Islands
- DNA Methylation
- Gene Silencing
- Genes, ras
- Transcription, Genetic