Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24623658.
- Also identified by DOI 10.1002/adhm.201400054 and PMC identifier 4160381.
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Abstract
New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.
Medical subject headings
- Gene Expression
- Gene Silencing
- Lipids
- Nanostructures
- Transfection