Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24626928.
- Also identified by DOI 10.1126/science.1248228 and PMC identifier 4097009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Vertebrate limbs first emerge as small buds at specific locations along the trunk. Although a fair amount is known about the molecular regulation of limb initiation and outgrowth, the cellular events underlying these processes have remained less clear. We show that the mesenchymal limb progenitors arise through localized epithelial-to-mesenchymal transition (EMT) of the coelomic epithelium specifically within the presumptive limb fields. This EMT is regulated at least in part by Tbx5 and Fgf10, two genes known to control limb initiation. This work shows that limb buds initiate earlier than previously thought, as a result of localized EMT rather than differential proliferation rates.
Medical subject headings
- Epithelial-Mesenchymal Transition
- Extremities
- Limb Buds