Sugarcoating ER Stress.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24630714.
- Also identified by DOI 10.1016/j.cell.2014.02.035.
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Abstract
The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.
Medical subject headings
- Biosynthetic Pathways
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA-Binding Proteins
- Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
- Hexosamines
- Longevity
- Proteins
- Transcription Factors
- Unfolded Protein Response