Inflammasome: putting the pieces together.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24630715.
- Also identified by DOI 10.1016/j.cell.2014.02.038.
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Abstract
Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inflammasome assembly.
Medical subject headings
- Biological Evolution
- Cytoskeletal Proteins
- Immunity, Innate
- Inflammasomes
- Prions
- Signal Transduction
- Yeasts