Silent mutations make some noise.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24630716.
- Also identified by DOI 10.1016/j.cell.2014.02.037.
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Abstract
Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.
Medical subject headings
- Mutation
- Neoplasms
- Oncogenes
- RNA Splice Sites