SnapShot: talin and the modular nature of the integrin adhesome.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24630731.
- Also identified by DOI 10.1016/j.cell.2014.02.048 and PMC identifier 4479492.
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Abstract
Integrin αβ transmembrane heterodimers play central roles in metazoan development and physiology by mediating adhesion and by transmitting forces and biochemical signals across the plasma membrane. In this SnapShot, we present a simplified "modular" view of the integrin adhesome, centered on the talin-integrin interaction, and provide examples of how this view can help to unravel the adhesome's remarkable functional diversity and plasticity.
Medical subject headings
- Integrins
- Talin