PyClone: statistical inference of clonal population structure in cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24633410.
- Also identified by DOI 10.1038/nmeth.2883 and PMC identifier 4864026.
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Abstract
We introduce PyClone, a statistical model for inference of clonal population structures in cancers. PyClone is a Bayesian clustering method for grouping sets of deeply sequenced somatic mutations into putative clonal clusters while estimating their cellular prevalences and accounting for allelic imbalances introduced by segmental copy-number changes and normal-cell contamination. Single-cell sequencing validation demonstrates PyClone's accuracy.
Medical subject headings
- Bayes Theorem
- Cluster Analysis
- Models, Biological
- Models, Statistical
- Neoplasms