Topical application of imiquimod as a treatment for chromoblastomycosis.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 24633683.
- Also identified by DOI 10.1093/cid/ciu168 and PMC identifier 4036686.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge, with no standard treatment and high rates of relapse. On the basis of our recent discoveries in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report results of treatment for the first 4 recipients of topical imiquimod, all of whom displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy.
Medical subject headings
- Adjuvants, Immunologic
- Aminoquinolines
- Ascomycota
- Chromoblastomycosis