Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection?
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 24633688.
- Also identified by DOI 10.1093/cid/ciu152.
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Abstract
The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI.
Medical subject headings
- Enterocolitis, Pseudomembranous
- Genetic Predisposition to Disease
- Interleukin-8
- Promoter Regions, Genetic