Amyloid-hydroxyapatite bone biomimetic composites.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24634054.
- Also identified by DOI 10.1002/adma.201306198.
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Abstract
A "bottom up" strategy is proposed to synthesize high aspect ratio hydroxyapatite (and brushite) platelets, and combine them with amyloid fibrils into layered hybrid nanocomposites. Their hierarchical structure, despite the differences from natural bone, confers to the nanocomposites a density and elastic modulus matching those of cancellous bone. Evidence of good adhesion and spreading of human trabecular bone-derived pre-osteoblasts cells on these nanocomposites is provided.
Medical subject headings
- Amyloid
- Biomimetic Materials
- Bone and Bones
- Durapatite
- Nanocomposites