Seeing the forest for the trees: kidney oncogenomes in relation to therapeutic outcomes.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 24634386.
- Also identified by DOI 10.1158/1078-0432.CCR-14-0056 and PMC identifier 4077661.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Renal cell carcinoma is a heterogeneous disease, and tissue investigations provide clues that may predict treatment response. Oncogenomic analysis of five outliers, who achieved a sustained response with rapalogs, implicates alterations of the TSC1 and mTOR genes and reveals insights into the conserved evolution of tumors.
Medical subject headings
- Carcinoma, Renal Cell
- Protein Kinase Inhibitors
- TOR Serine-Threonine Kinases