Capture and release of cancer cells based on sacrificeable transparent MnO2 nanospheres thin film.

Huang, Qinqin; Chen, Bolei; He, Rongxiang; He, Zhaobo; Cai, Bo; Xu, Junhua; Qian, Weiyi; Chan, Helen Laiwa et al. · Adv Healthc Mater · 2014

basic_science · Level V

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Abstract

A CTCs detection assay using transparent MnO2 nanospheres thin films to capture and release of CTCs is reported. The enhanced local topography interaction between extracellular matrix scaffolds and the antibody-coated substrate leads to improved capture efficiency. CTCs captured from artificial blood sample can be cultured and released, represent a new functional material capable of CTCs isolation and culture for subsequent studies.

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