Ultracompact three-dimensional tubular conductivity microsensors for ionic and biosensing applications.
basic_science · Level V
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- Record sourced from PubMed, PMID 24655094.
- Also identified by DOI 10.1021/nl500795k and PMC identifier 3985718.
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Abstract
We present ultracompact three-dimensional tubular structures integrating Au-based electrodes as impedimetric microsensors for the in-flow determination of mono- and divalent ionic species and HeLa cells. The microsensors show an improved performance of 2 orders of magnitude (limit of detection = 0.1 nM for KCl) compared to conventional planar conductivity detection systems integrated in microfluidic platforms and the capability to detect single HeLa cells in flowing phosphate buffered saline. These highly integrated conductivity tubular sensors thus open new possibilities for lab-in-a-tube devices for bioapplications such as biosensing and bioelectronics.
Medical subject headings
- Biosensing Techniques
- Gold
- Ions
- Microfluidic Analytical Techniques
- Single-Cell Analysis