Assessing cellular response to functionalized α-helical peptide hydrogels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24659615.
- Also identified by DOI 10.1002/adhm.201400065 and PMC identifier 4276410.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.
Medical subject headings
- Biocompatible Materials
- Cell Proliferation
- Hydrogels
- Peptides