Directed axonal outgrowth using a propagating gradient of IGF-1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24664530.
- Also identified by DOI 10.1002/adma.201305995.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The temporospatial regulation of axon outgrowth is useful for guiding de novo connectivity or re-connectivity of neurons in neurological injury or disease. Here we report the successful construction of a biocompatible guidance device, in which a linear propagation of IGF-1 gradient sequentially directs axon outgrowth. We observe the extensive in vitro axonal extension over 5 mm with a desired growth rate of ∼ 1 mm/day.
Medical subject headings
- Axons
- Insulin-Like Growth Factor I