Multifunctional PEGylated multiwalled carbon nanotubes for enhanced blood pool and tumor MR imaging.

Wen, Shihui; Zhao, Qinghua; An, Xiao; Zhu, Jingyi; Hou, Wenxiu; Li, Kai; Huang, Yunpeng; Shen, Mingwu et al. · Adv Healthc Mater · 2014

basic_science · Level V

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Abstract

Long-circulating multifunctional Gd(III)-loaded multiwalled carbon nanotubes (MWCNTs) modified with polyethylene glycol are designed and synthesized. The formed MWCNTs are water-dispersible, stable, and have good cytocompatibility and antifouling property. With the low r 2 /r 1 relaxivity ratio and relatively long blood circulation time, the multifunctional MWCNTs are able to be used as a platform for enhanced blood pool and tumor MR imaging.

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