Neutralized nanoparticle composed of SS-cleavable and pH-activated lipid-like material as a long-lasting and liver-specific gene delivery system.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24668914.
- Also identified by DOI 10.1002/adhm.201300629.
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Abstract
Charge-neutralized lipid envelope-type nanoparticles formed with SS-cleavable and pH-activated lipid-like materials (ssPalm) accumulate rapidly in the liver without forming aggregates in the blood circulation, and result in a liver-specific gene expression for a long duration (>2 weeks) with neither immunological responses nor hepatotoxicity after intraveneous administration, when it carries pDNA free from CpG-motifs.
Medical subject headings
- Disulfides
- Liver
- Nanoparticles