Comment on "drug discovery: turning the titanic".

Lesterhuis, W Joost; Bosco, Anthony; Lake, Richard A · Sci Transl Med · 2014

editorial · Level V

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Abstract

The pathobiology-based approach to research and development has been the dominant paradigm for successful drug discovery over the last decades. We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways.

Medical subject headings