Structure of the yeast mitochondrial large ribosomal subunit.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24675956.
- Also identified by DOI 10.1126/science.1249410 and PMC identifier 4046073.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large subunit using single-particle cryo-electron microscopy. The resolution of 3.2 angstroms enabled a nearly complete atomic model to be built de novo and refined, including 39 proteins, 13 of which are unique to mitochondria, as well as expansion segments of mitoribosomal RNA. The structure reveals a new exit tunnel path and architecture, unique elements of the E site, and a putative membrane docking site.
Medical subject headings
- Mitochondria
- Ribosome Subunits, Large, Eukaryotic
- Saccharomyces cerevisiae