Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 24676965.
- Also identified by DOI 10.1192/bjp.bp.113.132977.
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Abstract
Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.
Medical subject headings
- Attention Deficit Disorder with Hyperactivity
- Dopamine Plasma Membrane Transport Proteins
- Impulsive Behavior
- Methylphenidate