Rethinking differentiation: stem cells, regeneration, and plasticity.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24679530.
- Also identified by DOI 10.1016/j.cell.2014.02.041 and PMC identifier 4074550.
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Abstract
Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated cell. Past and recent discoveries in plants and animals, as well as novel experimental manipulations, are beginning to erode many of these established concepts and are forcing a re-evaluation of the experimental systems and paradigms presently being used to explore these and other biological process.
Medical subject headings
- Cell Differentiation
- Stem Cells