The virome in mammalian physiology and disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24679532.
- Also identified by DOI 10.1016/j.cell.2014.02.032 and PMC identifier 3977141.
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Abstract
The virome contains the most abundant and fastest mutating genetic elements on Earth. The mammalian virome is constituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect the broad array of other types of organisms that inhabit us. Virome interactions with the host cannot be encompassed by a monotheistic view of viruses as pathogens. Instead, the genetic and transcriptional identity of mammals is defined in part by our coevolved virome, a concept with profound implications for understanding health and disease.
Medical subject headings
- Bacteriophages
- Mammals
- Microbiota
- Viruses