Sphingosine-1-phosphate receptor signaling during acute kidney injury: the tissue is the issue.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 24682118.
- Also identified by DOI 10.1038/ki.2013.435 and PMC identifier 4007344.
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Abstract
Sphingosine-1-phosphate is a lipid mediator that has been implicated in protection from acute kidney injury (AKI) by activation of the sphingosine-1-phosphate 1 receptor (S1P1R). The research team of H. Thomas Lee demonstrates that mice with induced deletion of S1P1R on endothelial cells experience increased ischemia-induced AKI. These findings have important translational implications. Indeed, S1P1R agonists have been used for the treatment of patients suffering from autoimmune encephalitis. Endothelial S1P1R signaling could be targeted for AKI prevention in surgical patients.
Medical subject headings
- Acute Kidney Injury
- Endothelium
- Epithelial Cells
- HSP27 Heat-Shock Proteins
- Kidney Tubules, Proximal
- Receptors, Lysosphingolipid
- Reperfusion Injury