Whisker barrel cortex delta oscillations and gamma power in the awake mouse are linked to respiration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24686563.
- Also identified by DOI 10.1038/ncomms4572 and PMC identifier 3988824.
- Licence recorded as CC BY-NC-SA.
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Abstract
Current evidence suggests that delta oscillations (0.5-4 Hz) in the brain are generated by intrinsic network mechanisms involving cortical and thalamic circuits. Here we report that delta band oscillation in spike and local field potential (LFP) activity in the whisker barrel cortex of awake mice is phase locked to respiration. Furthermore, LFP oscillations in the gamma frequency band (30-80 Hz) are amplitude modulated in phase with the respiratory rhythm. Removal of the olfactory bulb eliminates respiration-locked delta oscillations and delta-gamma phase-amplitude coupling. Our findings thus suggest respiration-locked olfactory bulb activity as a main driving force behind delta oscillations and gamma power modulation in the whisker barrel cortex in the awake state.
Medical subject headings
- Cerebral Cortex
- Mice
- Olfactory Bulb
- Respiration
- Vibrissae
- Wakefulness