Nanoengineered particles for enhanced intra-articular retention and delivery of proteins.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24687997.
- Also identified by DOI 10.1002/adhm.201400051 and PMC identifier 4182168.
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Abstract
Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.
Medical subject headings
- Drug Carriers
- Nanoparticles
- Proteins