Harnessing FOXP3+ regulatory T cells for transplantation tolerance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24691478.
- Also identified by DOI 10.1172/JCI67226 and PMC identifier 3973097.
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Abstract
Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.
Medical subject headings
- T-Lymphocytes, Regulatory
- Transplantation Tolerance