Endocytic capsule sensors for probing cellular internalization.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24700555.
- Also identified by DOI 10.1002/adhm.201400139.
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Abstract
A new class of polymer capsules with an in-built endocytic pH-coupled fluorescence switch is reported. These capsules display reversible "on/off" fluorescence in response to cellular pH variations. Using this system, the high-throughput quantification between surface-bound and internalized capsules is demonstrated. This system allows a fundamental study of the interaction between nanoengineered materials and biological systems at a cellular level.
Medical subject headings
- Drug Carriers
- Drug Delivery Systems
- Endocytosis
- Fluorescent Dyes
- Polymethacrylic Acids