How Tets and cytoskeleton dynamics MET in reprogramming.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24702989.
- Also identified by DOI 10.1016/j.stem.2014.03.007.
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Abstract
Two studies by Sakurai et al. (2014) and Hu et al. (2014) in this issue of Cell Stem Cell add a new level of understanding to the mesenchymal-to-epithelial transition taking place during reprogramming, showing how this morphological transformation is promoted by Tet enzymes and blocked by kinase-dependent cytoskeletal organization.
Medical subject headings
- Cell Differentiation
- Cellular Reprogramming
- Cytoskeleton
- DNA Glycosylases
- DNA Methylation
- DNA-Binding Proteins
- Embryonic Stem Cells
- Epithelial-Mesenchymal Transition
- Induced Pluripotent Stem Cells
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins