On the origin of leukemic species.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24702991.
- Also identified by DOI 10.1016/j.stem.2014.03.008.
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Abstract
Recent studies (Shlush et al., 2014; Corces-Zimmerman et al., 2014) have demonstrated that leukemias develop from hematopoietic stem cells that acquire preleukemic mutations, allowing clonal expansion and subsequent acquisition of mutations leading to cancer. Preleukemic cells survive chemotherapy and serve as reservoirs for disease, generating new clones and leading to relapse.
Medical subject headings
- Clonal Evolution
- Epigenesis, Genetic
- Hematopoietic Stem Cells
- Leukemia, Myeloid, Acute
- Models, Biological
- Neoplastic Stem Cells
- Preleukemia