Personalized platelet transfusions: one step closer to the clinic.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24702993.
- Also identified by DOI 10.1016/j.stem.2014.03.012.
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Abstract
In this issue of Cell Stem Cell, Nakamura et al. (2014) use human pluripotent stem cells to generate immortalized megakaryocyte progenitor cell lines that can be cryopreserved, expanded in vitro, and induced to undergo terminal maturation and platelet release. This strategy advances efforts to produce clinically relevant numbers of tissue-culture-derived platelets for transfusion therapies.
Medical subject headings
- Blood Platelets
- Cell Differentiation
- Embryonic Stem Cells
- Induced Pluripotent Stem Cells
- Megakaryocytes
- Thrombocytopenia