Metabolism goes viral.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 24703688.
- Also identified by DOI 10.1016/j.cmet.2014.03.022 and PMC identifier 4097405.
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Abstract
Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides for viral replication.
Medical subject headings
- Adenovirus E4 Proteins
- Epithelial Cells
- Glucose
- Metabolic Networks and Pathways
- Models, Biological
- Proto-Oncogene Proteins c-myc
- Virus Replication