Small molecules convert fibroblasts into islet-like cells avoiding pluripotent state.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24703689.
- Also identified by DOI 10.1016/j.cmet.2014.03.019.
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Abstract
Obtaining large numbers of functional pancreatic islets via direct cellular reprogramming is an important clinically relevant goal. In a recent issue of Cell Stem Cell, Li et al. (2014) report a new step-wise protocol for generating islet cells from mouse embryonic fibroblasts using a combination of soluble molecules.
Medical subject headings
- Cell Lineage
- Cellular Reprogramming
- Fibroblasts
- Pancreas
- Small Molecule Libraries