Lipotoxicity, β cell dysfunction, and gestational diabetes.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24703690.
- Also identified by DOI 10.1016/j.cmet.2014.03.020.
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Abstract
Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.
Medical subject headings
- Furans
- Insulin-Secreting Cells
- Mitochondria
- Models, Biological
- Organic Anion Transporters, Sodium-Independent
- Propionates