Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24711251.
- Also identified by DOI 10.1002/adma.201400154 and PMC identifier 4122615.
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Abstract
A virus-activated matrix is developed to overcome the challenge of forming vascularized bone tissue. It is generated by filling a 3D printed bioceramic scaffold with phage nanofibers displaying high-density RGD peptide. After it is seeded with mesenchymal stem cells (MSCs) and implanted into a bone defect, the phage nanofibers induce osteogenesis and angiogenesis by activating endothelialization and osteogenic differentiation of MSCs.
Medical subject headings
- Bacteriophages
- Biocompatible Materials
- Bone and Bones
- Nanofibers
- Neovascularization, Physiologic
- Osteogenesis
- Printing, Three-Dimensional