Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 24718556.
- Also identified by DOI 10.1371/journal.pone.0094496 and PMC identifier 3981814.
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Abstract
The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we found that the production of proinflammatory cytokines was drastically suppressed in monocytes and macrophages. Further study revealed that the suppression was mainly related to the mammalian target of rapamycin (mTOR)/p70(S6K) signaling. In addition, we found that the PI3K pathway was involved in macrophage motility and neovascularization. Our data provide a rationale that inhibition of the PI3K signaling pathway could be an attractive approach for the management of inflammatory disorders.
Medical subject headings
- Immunity, Innate
- Macrophages
- Monocytes
- Phosphatidylinositol 3-Kinase
- Proto-Oncogene Proteins c-akt
- Signal Transduction
- TOR Serine-Threonine Kinases