HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 24719475.
- Also identified by DOI 10.1093/infdis/jiu214 and PMC identifier 4215081.
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Abstract
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.
Medical subject headings
- Disease Resistance
- HIV Infections
- Hemophilia A
- Histocompatibility Antigens Class I
- Receptors, KIR