A single misstep in cardiac development explains the co-occurrence of tetralogy of fallot and complete atrioventricular septal defect in Down syndrome.
Where this comes from
- Record sourced from PubMed, PMID 24721467.
- Also identified by DOI 10.1016/j.jpeds.2014.02.065 and PMC identifier 4074567.
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Abstract
Tetralogy of Fallot and a complete atrioventricular septal defect are thought to arise by distinct mechanisms, yet their co-occurrence is a recognized association. Analysis of the prevalence of co-occurrence in Down syndrome suggests a common developmental basis. Trisomy 21 may perturb cardiac progenitor cells before they enter the heart tube.
Medical subject headings
- Down Syndrome
- Mitral Valve Insufficiency
- Tetralogy of Fallot