Fabrication of a multifunctional nano-in-micro drug delivery platform by microfluidic templated encapsulation of porous silicon in polymer matrix.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24737409.
- Also identified by DOI 10.1002/adma.201400953.
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Abstract
A multifunctional nano-in-micro drug delivery platform is developed by conjugating the porous silicon nanoparticles with mucoadhesive polymers and subsequent encapsulation into a pH-responsive polymer using microfluidics. The multistage platform shows monodisperse size distribution and pH-responsive payload release, and the released nanoparticles are mucoadhesive. Moreover, this platform is capable of simultaneously loading and releasing multidrugs with distinct properties.
Medical subject headings
- Drug Delivery Systems
- Silicon