Acute retinal necrosis associated with Epstein-Barr virus: immunohistopathologic confirmation.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 24743882.
- Also identified by DOI 10.1001/jamaophthalmol.2014.266 and PMC identifier 4143326.
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Abstract
Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history and histopathologic confirmation that EBV can cause ARN. Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.
Medical subject headings
- Epstein-Barr Virus Infections
- Eye Infections, Viral
- Herpesvirus 4, Human
- Retinal Necrosis Syndrome, Acute