Human somatic cell nuclear transfer using adult cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24746675.
- Also identified by DOI 10.1016/j.stem.2014.03.015.
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Abstract
Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of therapeutic contexts. However, successful SCNT with human cells has proved challenging to achieve, and thus far has only been reported with fetal or infant somatic cells. In this study, we describe the application of a recently developed methodology for the generation of human ESCs via SCNT using dermal fibroblasts from 35- and 75-year-old males. Our study therefore demonstrates the applicability of SCNT for adult human cells and supports further investigation of SCNT as a strategy for regenerative medicine.
Medical subject headings
- Adult Stem Cells
- Nuclear Transfer Techniques
- Pluripotent Stem Cells